<p><p><a title="Overview" href='http://www.allostery2013.org/index.asp?page_id=1'>Overview</a></p><p><a title="Organizers" href='http://www.allostery2013.org/index.asp?page_id=34'>Organizers</a></p><p><a title="Scientific Program" href='http://www.allostery2013.org/index.asp?page_id=35'>Scientific Program</a></p><p><a title="Scientific Program" href='http://www.allostery2013.org/index.asp?page_id=14'>Scientific Program</a></p><p><a title="Speakers" href='http://www.allostery2013.org/index.asp?page_id=15'>Speakers</a></p><p><a title="Online registration" href='http://www.allostery2013.org/index.asp?page_id=16'>Online registration</a></p><p><a title="Call for abstracts" href='http://www.allostery2013.org/index.asp?page_id=17'>Call for abstracts</a></p><p><a title="Fellowships" href='http://www.allostery2013.org/index.asp?page_id=28'>Fellowships</a></p><p><a title="Request of Visa" href='http://www.allostery2013.org/index.asp?page_id=31'>Request of Visa</a></p><p><a title="Venue" href='http://www.allostery2013.org/index.asp?page_id=18'>Venue</a></p><p><a title="Social program" href='http://www.allostery2013.org/index.asp?page_id=19'>Social program</a></p><p><a title="Sponsors" href='http://www.allostery2013.org/index.asp?page_id=20'>Sponsors</a></p><p><a title="Accommodation" href='http://www.allostery2013.org/index.asp?page_id=21'>Accommodation</a></p><p><a title="Practical information" href='http://www.allostery2013.org/index.asp?page_id=22'>Practical information</a></p><p><a title="Contact us" href='http://www.allostery2013.org/index.asp?page_id=23'>Contact us</a></p><table class="tab_layout"> <tbody> <tr> <td class="bgauche"><br /></td> <td> <p> </p> <p><strong><span style="font-family: arial, helvetica, sans-serif; font-size: medium;">WELCOMING DESK OPENS AT NOON on May 14th, 2013</span></strong></p> <p><strong><span style="font-family: arial, helvetica, sans-serif; font-size: medium;">OPENING SESSION STARTS AT 2PM IN THE MAIN AUDITORIUM </span></strong></p> <p><span style="font-family: 'arial black', 'avant garde'; font-size: medium;"> </span></p> <h1><strong>Overview</strong></h1> <div style="text-align: justify;"> <p>In the 50 years since the introduction of “allosteric interactions,” this concept has become one of the pillars of structural, molecular and cell biology, along with the flow of information via the genetic code, since regulation must continually modulate biological processes. To mark the half-century of research on allosteric interaction, a major conference will be held at the Institut Pasteur on May 14-17, 2013. Over 40 leading scientists will present current research issues and developments involving all forms of allosteric interactions and their implications for cell signaling.</p> <h2><strong>Read the articles about:</strong></h2> </div> <p><strong><a href="http://www.pasteur.fr/ip/resource/filecenter/document/01s-00004j-0eq/monod-changeux-jacob-1963.pdf" target="_blank">Allosteric Proteins and Cellular Control Systems</a></strong></p> <p>Jacques MONOD, Jean Pierre CHANGEUX and François JACOB, 1963</p> <p><strong><a href="http://www.pasteur.fr/ip/resource/filecenter/document/01s-00004j-0er/monod-wyman-changeux-1965.pdf" target="_blank">On the Nature of Allosteric Transitions : A Plausible Model</a> </strong></p> <p><span style="color: #232323;"><strong>J</strong>acques MONOD, Jeffryes WYMAN and Jean Pierre CHANGEUX 1965</span></p> <h5> </h5> <h2><span style="color: #2b6312;"><strong>Special JMB Issue Allo<span style="color: #2b6012;">stery reviews: </span></strong></span></h2> <span style="color: #2b6312;"> </span> <p><a href="http://www.sciencedirect.com/science/article/pii/S002228361300123X"><span style="color: #84ae03;"><strong>Virus Assembly and Maturation: Auto-Regulation through Allosteric Molecular Switches</strong></span></a></p> <p><span style="color: #84ae03;"><strong><a href="http://www.sciencedirect.com/science/article/pii/S0022283613000685">Allosteric Effects in the Regulation of 26S Proteasome Activities</a><br /></strong></span></p> <p><a href="http://www.sciencedirect.com/science/article/pii/S0022283613000430"><span style="color: #84ae03;"><strong>The Energy and Work of a Ligand-Gated Ion Channel</strong></span></a></p> <p><a href="http://www.sciencedirect.com/science/article/pii/S0022283612009412"><span style="color: #84ae03;"><strong>The Propagation of Allosteric States in Large Multiprotein Complexes</strong></span></a></p> <p><a href="http://www.sciencedirect.com/science/article/pii/S002228361200900X"><span style="color: #84ae03;"><strong>Structure and Allostery of the Chaperonin GroEL</strong></span></a></p> <h2><span style="color: #2b6312;"><strong>Special JMB Issue Allo<span style="color: #2b6012;">stery communications: </span></strong></span></h2> <p><a href="http://www.sciencedirect.com/science/article/pii/S0022283613000703"><span style="color: #84ae03;"><strong>Hidden Allostery in Human Glutathione Transferase P1-1 Unveiled by Unnatural Amino Acid Substitutions and Inhibition Studies</strong></span></a></p> <p> </p> <h2><span style="color: #2b6012;"><strong>Full Length JMB Articles:</strong></span></h2> <p><a href="http://www.sciencedirect.com/science/article/pii/S0022283613000466"><span style="color: #84ae03;"><strong>Long-Range Interactions in the Alpha Subunit of Tryptophan Synthase Help to Coordinate Ligand Binding, Catalysis, and Substrate Channeling</strong></span></a></p> <p><a href="http://www.sciencedirect.com/science/article/pii/S0022283613000442"><span style="color: #84ae03;"><strong>The Tropomyosin Binding Region of Cardiac Troponin T Modulates Crossbridge Recruitment Dynamics in Rat Cardiac Muscle Fibers</strong></span></a></p> <p><a href="http://www.sciencedirect.com/science/article/pii/S0022283612009515"><span style="color: #84ae03;"><strong>Hemoglobin Allostery: New Views on Old Players</strong></span></a></p> <p><a href="http://www.sciencedirect.com/science/article/pii/S0022283612009175"><span style="color: #84ae03;"><strong>The Membrane-Binding Domain of an Amphitropic Enzyme Suppresses Catalysis by Contact with an Amphipathic Helix Flanking Its Active Site</strong></span></a></p> </td> <td style="text-align: center;" align="center" valign="middle"> </td> <td style="text-align: center;" align="center" valign="middle"> <p> </p> <p> <img src="http://www.allostery2013.org/Images/Public/EMBO_logo_tagline_narrow_RGBblack_outlined.gif" alt="" width="100" height="108" /></p> <p><img src="http://www.allostery2013.org//images/EMBO_Conference_stamp_web_LIGHT.png" alt="" width="100" height="100" /></p> <p><span style="text-align: left;"> </span><img style="text-align: left;" src="http://www.allostery2013.org/Images/Public/LogoPasteurCourrier.gif" alt="" width="140" height="52" /></p> <p> </p> <p> <img style="font-family: 'Helvetica Neue', Arial, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant: normal; line-height: 18px; text-align: left;" src="http://www.allostery2013.org/Images/Public/sanofi-logo.jpg" alt="" width="77" height="56" /></p> <p> </p> <p> </p> </td> </tr> </tbody> </table></p><p><p> </p> <table class="tab_layout"> <tbody> <tr> <td class="bgauche"><br /></td> <td> <h1><strong>Scientific program</strong></h1> <h3 style="text-align: center;"><span style="color: #af290e; font-size: large;"><strong><em>PRELIMINARY PROGRAM</em></strong></span></h3> <p><span style="font-size: medium;"><strong><span style="font-family: Verdana,Arial,Helvetica,sans-serif; line-height: 1.5;"> </span></strong></span><strong><strong style="color: #2b6012; font-family: 'Titillium Web', sans-serif; font-size: 2em; line-height: 1;">Tuesday,</strong></strong><strong><strong style="color: #2b6012; font-family: 'Titillium Web', sans-serif; font-size: 2em; line-height: 1;"> M</strong></strong><strong><strong style="color: #2b6012; font-family: 'Titillium Web', sans-serif; font-size: 2em; line-height: 1;">ay</strong></strong><strong><strong style="color: #2b6012; font-family: 'Titillium Web', sans-serif; font-size: 2em; line-height: 1;"> 14, Afternoon</strong></strong></p> <table border="0"> <tbody> <tr> <td> <p><strong>Opening Session: </strong></p> <p><strong>Chair:</strong></p> <p>2:00- 3:00</p> </td> <td> <p> <strong>HISTORY OF ALLOSTERY</strong></p> <p> François GROS</p> <p><span style="font-size: 12px;">Welcoming remarks: Stuart EDELSTEIN, Alice DAUTRY</span></p> </td> </tr> <tr> <td> </td> <td>Keynote lecture: Jean-Pierre CHANGEUX “Historical Perspective”</td> </tr> <tr> <td><span style="font-family: verdana, geneva;"> </span></td> <td><span style="font-family: verdana, geneva;"> </span></td> </tr> <tr> <td><strong>Plenary Session:</strong></td> <td><strong>PROTEIN DYNAMICS</strong></td> </tr> <tr> <td><strong>Chairs:</strong></td> <td>Marc DELARUE and Joël JANIN</td> </tr> <tr> <td> </td> <td><span style="font-size: x-small;"><em>Sessions sponsored by Sanofi - Aventis Research and Development</em></span></td> </tr> <tr> <td>3:00-3:30</td> <td>Jean-Marie LEHN “Towards Adaptive Chemistry: Constitutional and Allosteric Dynamics”</td> </tr> <tr> <td>3:30-4:00</td> <td> <p>Kurt WüTHRICH “Allostery in Hemoglobin and GPCRs Viewed by NMR”</p> </td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>4:00-4:30</td> <td>Coffee break</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>4:30-5:00</td> <td>Peter WRIGHT “Exploring protein energy landscapes by NMR relaxation”</td> </tr> <tr> <td>5:00-5:30</td> <td>Martin KARPLUS,"Hemoglobin: New Insights into Old Questions"</td> </tr> <tr> <td>5:30-6:00</td> <td>Dennis BRAY “Propagation of allosteric states in large protein assemblies”</td> </tr> <tr> <td>6:00-6:30</td> <td>Charalampos KALODIMOS" Allosteric interactions mediated by internal dynamics"</td> </tr> <tr> <td>6:30-7:00</td> <td>2 short talks</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>7:00-8:30</td> <td>Welcoming cocktail</td> </tr> </tbody> </table> <p> </p> <p><span style="font-size: 12px; font-family: Verdana, Arial, Helvetica, sans-serif; line-height: 1.5;"> </span><strong style="color: #2b6012; font-family: 'Titillium Web', sans-serif; font-size: 2em; line-height: 1;">Wednesday, May 15, Morning</strong></p> <table border="0"> <tbody> <tr> <td style="width: 150px;"><strong>Plenary Session:</strong></td> <td><strong>ALLOSTERIC ENZYMES</strong></td> </tr> <tr> <td><strong>Chairs: </strong></td> <td>Maurizio BRUNORI and Pedro ALZARI</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>9:00-9:30</td> <td>John WALKER, "Regulation of ATP synthases"</td> </tr> <tr> <td>9:30-10:00</td> <td>Avram HERSHKO, "Regulation of APC/C ubiquitin ligase in the cell cycle"</td> </tr> <tr> <td>10:00-10:30</td> <td>Susan TAYLOR “PKA: Assembly of Dynamic Macromolecular Signaling Complexes”</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>10:30-11:00</td> <td>Coffee break</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>11:00-11:30</td> <td>Wendell LIM “Modular allosteric signaling proteins”</td> </tr> <tr> <td>11:30-12:00</td> <td>Wolfgang BAUMEISTER “The 26S proteasome: A molecular machine designed for controlled proteolysis”</td> </tr> <tr> <td>12:00-12:30</td> <td>2 short talks- to be selected</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>12:30-2:00</td> <td>Lunch and poster viewing</td> </tr> </tbody> </table> <p> </p> <p><span style="font-size: 12px; font-family: Verdana, Arial, Helvetica, sans-serif; line-height: 1.5;"> </span><strong style="font-family: Verdana, Arial, Helvetica, sans-serif; line-height: 1.5;"><span style="color: #2b6012; font-family: 'Titillium Web', sans-serif; font-size: 2em; line-height: 1;">Afternoon</span></strong></p> <table border="0"> <tbody> <tr> <td style="width: 150px;"><strong>Plenary Session:</strong></td> <td><strong>CHAPERONS AND MOTORS</strong></td> </tr> <tr> <td><strong>Chairs:</strong></td> <td>Marie-France CARLIER</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>2:00-2:30</td> <td>Arthur HORWICH “Allosteric movements drive protein folding by GroEL/GroES”</td> </tr> <tr> <td>2:30-3:00</td> <td>Helen SAIBIL "Dynamics and allostery of chaperonin complexes in assisted protein folding"</td> </tr> <tr> <td>3:00-3:30</td> <td>Anne HOUDUSSE “Allostery in molecular motors convert chemical energy into force production”</td> </tr> <tr> <td>3:30-4:00</td> <td>Coffee break</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td><strong>Plenary Session:</strong></td> <td><strong>VIRUSES</strong></td> </tr> <tr> <td><strong>Chairs:</strong></td> <td>Gerard ORTH</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>4:00-4:30</td> <td>Felix REY "Alphavirus entry:conformational changes and membrane fusion.Insight from structural studies"</td> </tr> <tr> <td>4:30-5:00</td> <td>Jack JOHNSON “Biophysical studies of virus maturation reveals allosteric behavior of capsid subunits”</td> </tr> <tr> <td>5:00-5:30</td> <td>Núria VERDAGUER “Structural Dynamics of the Vault Ribonucleoprotein Particle: </td> </tr> <tr> <td> </td> <td>A versatile Signal Regulation and Transport Platform”</td> </tr> <tr> <td>5:30-7:00</td> <td>6 Short talks-to be selected</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>7:00-9:00</td> <td>Poster session along with wine and cheese party</td> </tr> </tbody> </table> <p> </p> <p><strong style="font-family: Verdana, Arial, Helvetica, sans-serif; line-height: 1.5;"><strong style="color: #2b6012; font-family: 'Titillium Web', sans-serif; font-size: 2em; line-height: 1;">Thursday, May 16, Morning</strong></strong></p> <table border="0"> <tbody> <tr> <td style="width: 150px;"><strong>Plenary Session:</strong></td> <td><strong>RECEPTOR ION CHANNELS</strong></td> </tr> <tr> <td><strong>Chairs:</strong></td> <td>Palmer TAYLOR and Michaël NILGES</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>9:00-9:30</td> <td>Pierre-Jean CORRINGER "An intermediate conformation for the allosteric gating of pentameric cys-loop channel receptors"</td> </tr> <tr> <td>9:30-10:00</td> <td>Stuart EDELSTEIN "<span style="font-size: 11pt; font-family: 'Calibri','sans-serif'; color: #000000;">Cooperativity of Allosteric Receptors"</span></td> </tr> <tr> <td>10:00-10:30</td> <td>Karl DEISSEROTH (Optogenetics)</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>10:30-11:00</td> <td>Coffee break</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>11:00-11:30</td> <td>Anthony AUERBACH “Design and control of acetylcholine receptor-channels”</td> </tr> <tr> <td>11:30-12:00</td> <td>Lucia SIVILOTTI “Single molecule experimental insights into the activation of ligand-gated channels”</td> </tr> <tr> <td>12:00-12:30</td> <td>2 Short talks</td> </tr> <tr> <td>12:30-2:00</td> <td>Lunch and poster viewing</td> </tr> </tbody> </table> <p> </p> <p><strong style="color: #2b6012; font-family: 'Titillium Web', sans-serif; font-size: 2em; line-height: 1;">Afternoon</strong></p> <table border="0"> <tbody> <tr> <td style="width: 150px;"><strong>Plenary Session:</strong></td> <td><strong>MEMBRANE PROTEINS</strong></td> </tr> <tr> <td><strong>Chairs: </strong></td> <td>Eva PEBAY-PEYROULA and Joël BOCKAERT</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>2:00-2:30</td> <td>Brian KOBILKA “Structural insights into allosteric regulation of G protein coupled receptors”</td> </tr> <tr> <td>2:30-3:00</td> <td>Heidi HAMM “Dynamics of G protein activation by GPCRs”</td> </tr> <tr> <td>3:00-3:30</td> <td>Jean Philippe PIN “Metabotropic glutamate receptors: allosteric machines tuning synaptic activity”</td> </tr> <tr> <td>3:30-4:00</td> <td>Joseph SCHLESSINGER “Cell Signaling by Receptor Tyrosine Kinases; from basic principles to cancer therapy”</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>4:00-4:30</td> <td>Coffee break</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>4:30-5:00</td> <td>John KURIYAN, Allostery in Calcium/Calmodulin-Dependent Kinase-II</td> </tr> <tr> <td>5:00-5:30</td> <td>Gunnar VON HEIJNE "Translocon-mediated insertion and folding of membrane proteins"</td> </tr> <tr> <td>5:30-6:00</td> <td>Nicolas REYES “Excitatory Amino Acid Transporters: trimeric proteins with intra-subunit allostery”</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>7:15</td> <td>Conference dinner "Maison de la Chimie" Paris</td> </tr> </tbody> </table> <p> </p> <p><span style="font-size: 12px; font-family: Verdana, Arial, Helvetica, sans-serif; line-height: 1.5;"> </span><strong style="font-family: Verdana, Arial, Helvetica, sans-serif; line-height: 1.5;"><strong style="color: #2b6012; font-family: 'Titillium Web', sans-serif; font-size: 2em; line-height: 1;">Friday, May 17, Morning</strong></strong></p> <table border="0"> <tbody> <tr> <td style="width: 150px;"><strong>Plenary Session:</strong></td> <td><strong>REPLICATION AND GENE EXPRESSION</strong></td> </tr> <tr> <td><strong>Chairs:</strong></td> <td>André SENTENAC and Margaret BUCKINGHAM</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>9:00-9:30</td> <td>Michael BOTCHAN “Controlling the switch to S Phase in the cell cycle: Activation of the MCM helicase”</td> </tr> <tr> <td>9:30-10:00</td> <td>Mitchell LEWIS "Allostery and the Lac Operon"</td> </tr> <tr> <td>10:00-10:30</td> <td>Daniella RHODES “Chromatin structure and its regulation”</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>10:30-11:00</td> <td>Coffee break</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>11:00-11:30</td> <td>Dino MORAS “Allosteric control of coactivator recruitment by Nuclear Hormone Receptors”</td> </tr> <tr> <td>11:30-12:30</td> <td>4 short talks</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>12:30-2:00</td> <td>Lunch and poster viewing</td> </tr> </tbody> </table> <p> </p> <p><span style="font-size: 12px; font-family: Verdana, Arial, Helvetica, sans-serif; line-height: 1.5;"><strong style="color: #2b6012; font-family: 'Titillium Web', sans-serif; font-size: 2em; line-height: 1;">Afternoon</strong></span></p> <table border="0"> <tbody> <tr> <td style="width: 150px;"><strong>Plenary Session:</strong></td> <td><strong>RIBOSOMES, RNA, AND RIBO-SWITCHES</strong></td> </tr> <tr> <td><strong>Chairs: </strong></td> <td>Antoine DANCHIN and Alain JACQUIER</td> </tr> <tr> <td> </td> <td><span style="font-size: x-small;"><em>Sessions sponsored by Sanofi - Aventis Research and Development</em></span></td> </tr> <tr> <td>2:00-2:30</td> <td>Venki RAMAKRISHNAN "Canonical and unusual modes of decoding by the ribosome"</td> </tr> <tr> <td>2:30-3:00</td> <td>Ada YONATH " Induced fit, internal dynamics and propagation of allosteric states facilitate smooth as well as hampered function of ribosomes"</td> </tr> <tr> <td>3:00-3:30</td> <td>Jennifer A. DOUDNA “The helical handshake: Understanding how RNA structure affects regulatory RNA processing”</td> </tr> <tr> <td>3:30-4:00</td> <td>Poul NISSEN "On allosteric regulation of P-type ATPase ion pumps"</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>4:00-4:30</td> <td>Coffee break</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td>4:30-5:00</td> <td>Marat YUSUPOV “Structure of bacterial and yeast ribosome”</td> </tr> <tr> <td>5:00-5:30</td> <td>Elena CONTI “Allosteric regulation in the multi-subunit RNA exosome complex”</td> </tr> <tr> <td>5:30- 6:15</td> <td>3 short talks</td> </tr> <tr> <td>6:15-7:00</td> <td>Rob PHILIPS “Closing remarks”</td> </tr> <tr> <td> </td> <td> </td> </tr> <tr> <td><em><strong> </strong></em></td> <td> </td> </tr> </tbody> </table> </td> </tr> </tbody> </table> <p> </p></p><p><table class="tab_layout"> <tbody> <tr> <td class="bgauche"><br /></td> <td> <h1><strong>Speakers</strong></h1> <table width="100%" border="1"> <tbody> <tr> <td> </td> <td>AUERBACH Anthony, School of Medecine and Biomedical Sciences, Buffalo, USA</td> </tr> <tr> <td> </td> <td>BAUMEISTER Wolfgang, Max Planck Institute of Biochemistry, Martinsried, Germany</td> </tr> <tr> <td> </td> <td>BOTCHAN Michael, University of California, Berkeley, USA</td> </tr> <tr> <td> </td> <td>BRAY Dennis University of Cambridge, Cambridge, UK</td> </tr> <tr> <td> </td> <td>CHANGEUX Jean-Pierre, Institut Pasteur, Paris, France</td> </tr> <tr> <td> </td> <td>CONTI Elena, Max Planck Institute of Biochemistry, Martinsried, Germany</td> </tr> <tr> <td> </td> <td>CORRINGER Pierre Jean, Institut Pasteur, Paris, France</td> </tr> <tr> <td> </td> <td>DEISSEROTH Karl, Stanford University, Stanford, USA</td> </tr> <tr> <td> </td> <td>DOUDNA Jennifer, University of California, Berkeley, USA</td> </tr> <tr> <td> </td> <td>EDELSTEIN Stuart, University of Geneva, Geneva, Switzerland</td> </tr> <tr> <td> </td> <td>HAMM Heidi, Vanderbilt University, Nashville, USA</td> </tr> <tr> <td> </td> <td>HERSHKO Avram, Technion, Haifa, Israel</td> </tr> <tr> <td> </td> <td>HORWICH Arthur, Yale School of medicine, New haven, USA</td> </tr> <tr> <td> </td> <td>HOUDUSSE Anne, Institut Curie, Paris, France</td> </tr> <tr> <td> </td> <td>JOHNSON Jack, The Scripps Research Institute, La Jolla, USA</td> </tr> <tr> <td> </td> <td>KALODIMOS Charalampos, Rutgers University, Piscataway, USA</td> </tr> <tr> <td> </td> <td>KARPLUS Martin, Harvard University, Cambridge, USA</td> </tr> <tr> <td> </td> <td>KOBILKA Brian, Stanford University, Stanford, USA</td> </tr> <tr> <td> </td> <td>KURIYAN John, University of California, Berkeley, USA</td> </tr> <tr> <td> </td> <td>LEHN Jean-Marie, Université Louis Pasteur, Strasbourg, France</td> </tr> <tr> <td> </td> <td>LEWIS Mitchell, University of Pennsylvania, Philadelphia, USA</td> </tr> <tr> <td> </td> <td>LIM Wendell, UCSF, San Francisco, USA</td> </tr> <tr> <td> </td> <td>MORAS Dino, IGBMC, Strasbourg, France</td> </tr> <tr> <td> </td> <td>NISSEN Poul, University of Aarhus, Aarhus, Denmark</td> </tr> <tr> <td> </td> <td>PHILLIPS Rob, Caltech, Pasadena, USA</td> </tr> <tr> <td> </td> <td>PIN Jean Philippe, CNRS, Montpellier, France</td> </tr> <tr> <td> </td> <td>RAMAKRISHNAN Venki, LMB, Cambridge, UK</td> </tr> <tr> <td> </td> <td>REY Felix, Institut Pasteur, Paris, France</td> </tr> <tr> <td> </td> <td>REYES Nicolas, Institut Pasteur, Paris, France</td> </tr> <tr> <td> </td> <td>RHODES Daniela, LMB, Cambridge, UK</td> </tr> <tr> <td> </td> <td>SAIBIL Helen, University of London, London, UK</td> </tr> <tr> <td> </td> <td>SCHLESSINGER Joseph, Yale School of Medicine, New haven, USA</td> </tr> <tr> <td> </td> <td>SIVILOTTI Lucia, University of London, London, UK</td> </tr> <tr> <td> </td> <td>TAYLOR Susan, UCSD, La Jolla, USA</td> </tr> <tr> <td> </td> <td>VERDAGUER Núria, IBM, Barcelona, Spain</td> </tr> <tr> <td> </td> <td>VON HEIJNE Gunnar, Stockholm University, Stockholm, Sweden</td> </tr> <tr> <td> </td> <td>WALKER John, MRC-Mitochondrial Biology Unit, Cambridge, UK</td> </tr> <tr> <td> </td> <td>WRIGHT Peter, The Scripps Research Institute, La Jolla, USA</td> </tr> <tr> <td> </td> <td>WÜTHRICH Kurt, ETH, Zurich, Switzerland - The Scripps Research Institute, La Jolla, USA</td> </tr> <tr> <td> </td> <td>YONATH Ada, Weizmann Institute of Science, Rehovot, Israel</td> </tr> <tr> <td> </td> <td>YUSUPOV Marat, IGBMC, Strasbourg, France</td> </tr> </tbody> </table> </td> </tr> </tbody> </table></p><p><table class="tab_layout"> <tbody> <tr> <td class="bgauche"><br /></td> <td> <h1>Request of visa</h1> <p><strong>For administrative reasons, we wish to inform all researchers (EU members exluded) who need a professionnal visa to attend this conference that any request of pre-registration certificate (or invitation letter) should be done 1 month before the conference at the latest.</strong></p> <p><span style="font-size: 12px; line-height: 1.5;">We advise you to check as soon as possible with the French consular services in your country to know the list of documents required and the waiting period to obtain your visa (variable from one country to another).</span></p> <p>Please note that the visa of French embassies and consulates are generally by appointment.</p> <p>In case of refusal of visas by the French authorities, the Institut Pasteur will not be held responsible if you are requested to cancel your participation to the conference.</p> <p><a href="http://www.pasteur.fr/ip/resource/filecenter/document/01s-00004i-00s/ambassades-et-consulats-etrangers-en-france.pdf" target="_blank">List of French embassies and consulates</a></p> <h2>Institut Pasteur Internal modality</h2> <p><strong>Please register first</strong><span style="color: #047237;"><strong> <a href="Page.asp?PAGE_ID=16" target="Page"><span style="color: #047237;">Online registration</span></a> </strong></span></p> <div>To be in accordance with the French law concerning the visa application,</div> <div>please fax to +33 1 40 61 37 21 or email to : allostery2013@pasteur.fr the following documents:</div> <div> </div> <ol> <li>A letter of affiliation (headed-notepaper) or professional card</li> <li>A copy of last degree (French or English translation if necessary)</li> <li>A copy of your passport</li> <li>Your personal or professional address where the original letter will be sent (Fax number optional)</li> </ol> <p>We will send you the certificate of pre-registration (or letter of invitation) <strong>by 72 hours after reception</strong> of all the requested documents above (week-end and legal holidays excluded) by Fax or E-mail (certified PDF document with legal electronic signature) <span style="text-decoration: underline;"><strong>and</strong></span> by <strong>regular mail</strong>.</p> <p><span>We wish to inform you that your file and personal data can be forwarded to the French consular services</span><span> upon their request only.</span></p> <p>PS : Our offices are closed on Saturdays and Sundays and on bank holidays.</p> </td> </tr> </tbody> </table></p><p><table class="tab_layout"> <tbody> <tr> <td class="bgauche"><br /></td> <td> <h1><strong>Conference Centre of the Institut Pasteur</strong></h1> <table border="0" cellspacing="2" cellpadding="0" align="left"> <tbody> <tr> <td style="text-align: left;" colspan="2"><strong><span style="color: #000000; font-size: 12px; text-align: left;">Centre d'Information Scientifique (CIS)</span></strong><span style="color: #000000; font-size: 12px; text-align: left;"> </span></td> </tr> <tr> <td style="text-align: center;"><img class="ed_contourimage" style="float: left; margin: 0px 5px;" src="http://www.30yearshiv.org/Images/Public/cis_small.jpg" alt="cis_small" width="329" height="329" /></td> <td style="text-align: left;"><span style="color: #000000; font-size: 12px; text-align: left;">The International Research Centre in Paris of the Institut Pasteur, organizes scientific, medical congresses and meetings on various themes all year long. </span><br style="color: #000000; text-align: left;" /><br style="color: #000000; text-align: left;" /><span style="color: #000000; font-size: 12px; text-align: left;">The Scientific Information Centre includes the </span><a style="font: inherit; background-color: #ffffff; text-align: left;" href="http://www.pasteur.fr/infosci/auditorium/audit-eng.html" target="_blank">Conference Centre</a><span style="color: #000000; font-size: 12px; text-align: left;">, the "Auditorium" with adjacent rooms for coffee breaks and posters. </span><br style="color: #000000; text-align: left;" /><br style="color: #000000; text-align: left;" /><span style="color: #000000; font-size: 12px; text-align: left;">Finally, a specific catering service allows lunches to be served in a dedicated space for congresses, the "Espace Congrès". </span><br style="color: #000000; text-align: left;" /><br style="color: #000000; text-align: left;" /><br style="color: #000000; text-align: left;" /><strong style="color: #000000; text-align: left;"><em style="font: inherit;">Note: For safety reasons, minors below the age of 16 years are not allowed onto the Pasteur Campus.</em></strong></td> </tr> <tr> <td style="text-align: center;"><img class="ed_contourimage" src="http://www.30yearshiv.org/Images/Public//PAGE__18__122012--18-2.jpeg" alt="" width="178" height="140" /></td> <td style="text-align: center;"><img class="ed_contourimage" src="http://www.30yearshiv.org/Images/Public//PAGE__18__122012--18-4.jpeg" alt="" width="177" height="139" /></td> </tr> <tr> <td style="text-align: center;" colspan="2">Address: Institut Pasteur, <a href="http://www.pasteur.fr/ip/easysite/pasteur/en/institut-pasteur/address-and-access/map-of-campus-28-rue-du-dr-roux" target="_blank">28 rue du Docteur Roux</a>, 75015 Paris, France</td> </tr> </tbody> </table> <p> </p> </td> </tr> </tbody> </table></p><p><table class="tab_layout"> <tbody> <tr> <td class="bgauche"><br /></td> <td> <h1><strong>Social program</strong></h1> <p>The gala dinner will be held on Thursday May 16, 2013 at the "Maison de la Chimie" at 7:30 pm</p> <div class="cont-photo-maisonchimie"><img class="ed_image_ombres photo-maisonchimie" src="http://www.allostery2013.org/Images/Public/maisonchimie/jardin1.jpg" alt="" width="179" height="95" /> <img class="ed_image_ombres photo-maisonchimie" src="http://www.allostery2013.org/Images/Public/maisonchimie/MC1.gif" alt="" width="179" height="95" /> <img class="ed_image_ombres photo-maisonchimie" src="http://www.allostery2013.org/Images/Public/maisonchimie/MC4.jpg" alt="" width="142" height="95" /><br /> <img class="ed_image_ombres photo-maisonchimie" src="http://www.allostery2013.org/Images/Public/maisonchimie/MC5.jpg" alt="" width="180" height="95" /> <img class="ed_image_ombres photo-maisonchimie" src="http://www.allostery2013.org/Images/Public/maisonchimie/MC6.jpg" alt="" width="63" height="95" /> <img class="ed_image_ombres photo-maisonchimie" src="http://www.allostery2013.org/Images/Public/maisonchimie/MC7.jpg" alt="" width="63" height="95" /></div> <p> </p> <p> </p> <p> </p> <p> </p> </td> </tr> </tbody> </table></p><p><table class="tab_layout"> <tbody> <tr> <td class="bgauche"><br /> </td> <td> <h1><strong>Sponsors</strong></h1> <p> </p> <p>The Congress Department of the Institut Pasteur <span id="result_box" lang="en"><span class="hps">is at your</span> <span class="hps">disposal for any information</span> <span class="hps">about the conference and</span> <span class="hps">related</span> <span class="hps">exhibition</span>:</span><br /> <br /> If you are interested in sponsoring our congress, please contact <a href="mailto:allostery2013@pasteur.fr?subject=Allosteric%202013%20Sponsorship%20information">Valerie Escande</a><br /> <br /> <span id="result_box" lang="en"><span class="hps">All</span> <span class="hps">sponsorship opportunities</span> </span><span id="result_box" lang="en"><span class="hps">and their</span> <span class="hps">prices </span></span><span id="result_box" lang="en"><span class="hps">are</span> <span class="hps">available</span> <span class="hps">in the </span></span><span id="result_box" lang="en"><span class="hps">sponsorship </span></span><a href="http://www.pasteur.fr/ip/resource/filecenter/document/01s-00004j-0ht/allosteric-sponsor-reservation-form.pdf" target="_blank">booklet</a><span id="result_box" lang="en"> </span></p> <p> </p> <table width="1173" border="0"> <tbody> <tr> <td align="center" valign="middle"> <img style="display: block; margin-left: auto; margin-right: auto;" src="http://www.allostery2013.org/Images/Public/EMBO_logo_tagline_narrow_RGBblack_outlined.gif" alt="" width="157" height="169" /> </td> <td style="vertical-align: middle;" align="center" valign="middle"> <p> <img style="display: block; margin-left: auto; margin-right: auto;" src="http://www.allostery2013.org/Images/Public/PAGE__20__042013--347-1.png" alt="" width="157" height="157" /></p> </td> <td style="text-align: center; vertical-align: middle;" align="center" valign="middle"><img src="http://www.allostery2013.org/Images/Public/logo_IPweb.jpg" alt="" width="190" height="72" /></td> </tr> <tr> <td valign="middle"> <p> </p> <p> </p> <p><img style="display: block; margin-left: auto; margin-right: auto;" src="http://www.allostery2013.org/Images/Public/sanofi-logo.jpg" alt="" width="147" height="108" /></p> <p> </p> </td> <td style="vertical-align: middle;" valign="middle"> <img style="display: block; margin-left: auto; margin-right: auto;" src="http://www.allostery2013.org/Images/Public/logofndationhugot1979.jpg" alt="" width="153" height="55" /></td> <td style="vertical-align: middle;" valign="middle"> <img style="display: block; margin-left: auto; margin-right: auto;" src="http://www.allostery2013.org//images/Public/PAGE__20__032013--347-3.jpg" alt="" width="100" height="71" /></td> </tr> </tbody> </table> <table border="0"> <tbody> <tr> <td colspan="3"> <table border="0"> <tbody> <tr> <td style="width: 25%;"> <table border="0"> <tbody> <tr> <td><img style="display: block; margin-left: auto; margin-right: auto;" src="http://www.allostery2013.org/Images/Public/Elsevierlogo360.gif" alt="" width="70" height="77" /></td> <td> <img style="display: block; margin-left: auto; margin-right: auto;" src="http://www.allostery2013.org/Images/Public/AFMlogo.jpg" alt="" width="80" height="47" /></td> </tr> <tr> <td> <img style="margin-right: auto; margin-left: auto; font-family: 'Helvetica Neue', Arial, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant: normal; line-height: 18px; text-align: right; display: block;" src="http://www.allostery2013.org/Images/Public/FEI_2C_100(1).jpg" alt="" width="150" height="74" /></td> <td> <img style="display: block; margin-left: auto; margin-right: auto;" src="http://www.allostery2013.org/Images/Public/PAGE__20__032013--347-2.jpg" alt="" width="150" height="53" /><br /><br /></td> </tr> </tbody> </table> <br /><br /><br /></td> </tr> <tr> <td style="width: 25%; text-align: right;"> <br /><br /></td> </tr> <tr> <td style="width: 25%;"> <p> </p> <p style="text-align: center;"> </p> </td> </tr> </tbody> </table> </td> </tr> </tbody> </table> <p> </p> <p> </p> <p> </p> <p> </p> </td> </tr> </tbody> </table></p><p><table class="tab_layout"> <tbody> <tr> <td class="bgauche"><br /></td> <td> <h1><strong>Practical information</strong></h1> <p class="p-header">Please note: The prices*, travelling times and addresses mentioned on this page are given for reference only. This information is subject to change. <br /> <br />*Available from July 2011</p> <h2>Language</h2> <p>The official language of the conference is English.</p> <h2>How to get to the Institut Pasteur?</h2> <ul class="link-group"> <li><a href="http://www.pasteur.fr/ip/easysite/pasteur/en/institut-pasteur/address-and-access/map-of-campus-28-rue-du-dr-roux" target="_blank">Map 28 rue du Dr Roux </a></li> </ul> <h2><span style="color: #2b6312;">By Metro</span><span style="font-size: medium;"><br /></span></h2> <ul class="link-group"> <li><a href="http://www.ratp.info/touristes/index.php?langue=en" target="_blank">Map of the metro network</a></li> <li><a href="http://www.ratp.fr/" target="_blank">RATP - Public transportation official Website</a></li> </ul> <div class="rich-text"> <p>Get off at either "Volontaires" (line 12) or "Pasteur" (lines 6 and 12) station. These stations are just at 5 minute walk from the Institut Pasteur.<br /> <br /> You can buy tickets at the Metro stations, RER stations, certain RATP commercial agencies, automatic dispensers at Roissybus stops, RATP desks in Orly or CDG airports.<br /> <br /> Ticket prices (same ticket for metro, bus and tram): <br /> 1 ticket T+ : € 1.70 <br /> Single-use ticket purchased onboard buses : € 1.90<br /> Book of 10 T+ tickets (standard fare) : € 12.50 <br /> <br /> Note: <br /> One ticket allows you to travel on the metro and includes all connections as long as you do not leave the metro network. <br /> For most bus and tram routes in Paris and Ile-de-France, one ticket is valid for a single journey without connections regardless of length. On some routes (Balabus, Noctambus, Orlybus, Roissybus, 221, 297, 299, 350 and 351) fares depend on journey length.</p> </div> <h2>By bus</h2> <ul class="link-group"> <li><a href="http://www.ratp.info/orienter/cv/cv_en/cartebus.php" target="_blank">Map of the bus routes</a></li> </ul> <div class="rich-text"><span style="font-size: xx-small;">Bus number 95 (Institut Pasteur stop, direction Porte de Vanves) stops in front of the Institute’s entrance. <br /> Bus numbers 39 and 70 (Volontaires-Vaugirard or Sèvres-Lecourbe stops) stop slightly further away (5 to 10 minute walk) and not far from Pasteur metro station.</span></div> <div class="rich-text"> </div> <h2>By car</h2> <div class="rich-text"><em>Rue du Docteur Roux</em> is a one way street and you pay for parking spaces. Paying public car parks are available at the following addresses: <br /> <br /> Sogeparc France <br /> 81 rue Falguière <br /> 75015 Paris <br /> Phone: +33 1 43 35 27 69 <br /> <br /> Car park <br /> 50 avenue du Maine <br /> 75015 Paris <br /> Direct access to Montparnasse station and TGV <br /> Phone: +33 1 43 21 50 30</div> <div class="rich-text"> </div> <h2>From airports</h2> <ul class="link-group"> <li><a href="http://www.aeroportsdeparis.fr/ADP/en-gb/passagers/home/" target="_blank">Aéroports de Paris</a></li> </ul> <div class="rich-text"> <p><strong><span style="color: #999999;">The journey from Paris airports to the Institut Pasteur takes a minimum of 45 minutes (if you are coming from Orly airport) and 90 minutes (if you are coming from Roissy-Charles de Gaulle airport) <br /> </span></strong></p> <ul> <li><strong>Orly Airport (South and West Terminal) <br /> </strong>Phone: +33 1 49 75 15 15 <br /> <br /> <a href="http://videocdn.airfrance.com/cars-airfrance/index_en.html" target="_blank">Cars Air France</a> <br /> Fare (information only): € 10.35 one-way / € 16.65 return (Paris-Montparnasse ) - Journey time : approx. 35 min <br /> Next you can either walk about 15 minutes or take the metro (line number 6 direction Charles de Gaulle - Etoile) to get from Montparnasse-Bienvenue station to Pasteur station (one stop). <br /> <br /> <strong>Orlyval shuttle train: </strong>You must buy a special ticket to travel between Paris and Orly via Antony which is valid throughout the metro and RER networks. Fare (information only): € 10,75 (ORLYVAL). <br /> From the Antony RER station, take RER line B in the direction of Gare du Nord or Aéroport Charles de Gaulle and get off at Denfert-Rochereau station. Next take the metro (line 6 direction Charles de Gaulle - Etoile) as far as the Pasteur station. <br /> <br /> <span style="color: #33cccc;"><strong><span style="color: #000000;">Orlybus:</span> </strong></span>You must also buy a special ticket to travel by bus between Paris (Terminus at Denfert-Rochereau) and Orly - Fare (information only): € 6,90 - Journey time: 20 to 30 min<br /> From Denfert-Rochereau take the metro (line 6 direction Charles de Gaulle - Etoile) as far as the Pasteur station. <br /> <br /> <strong>By taxi: </strong>If you prefer to travel by taxi, Paris taxis will cost you roughly € 40 per journey. <br /> <br /> Orlyrail shuttle will also take you to the RER C (Aéroport d’Orly station) <br /> <br /> Finally, the Jetbus will take you to the Villejuif-Aragon metro station, the terminus of line 7.</li> </ul> <ul> <li><strong>Roissy-Charles-de-Gaulle Airport (CDG1, CDG2 and CDG3 Terminal) <br /> </strong>Phone: +33 1 48 62 22 80 <br /> <br /> Different routes are possible from Roissy - Charles de Gaulle Airport: <br /> <br /> <a href="http://videocdn.airfrance.com/cars-airfrance/index_en.html" target="_blank">Cars Air France</a> (+33 1 41 56 89 00): <br /> Fare (information only): € 13.50 one-way / € 21.60 return (CdG - Porte Maillot - Arc de Triomphe ) - Journey time : approx. 45 min <br /> Fare (information only): € 14.85 one-way / € 24.30 return (CdG - Gare de Lyon - Gare Montparnasse) - Journey time : approx. 50 min <br /> <br /> <strong>Metro/RER:</strong> Go to the RER station at the airport accessible from Roissy 2, or use the free Aéroports de Paris shuttles if your flight lands at the other terminals. Buy a Paris metro ticket and take the RER B to Denfert-Rochereau (about € 9.10). Next take the metro (line 6 direction Charles de Gaulle-Etoile) as far as the Pasteur station - Journey time* : allow 1h30 (RER). <br /> <br /> <span style="color: #33cccc;"><strong><span style="color: #000000;">Roissybus:</span> </strong></span>This bus goes from the airport to rue Scribe, near <em>Place de l’Opéra</em>. <br /> Tickets are on sale at line terminuses, in the airports and Roissybus buses. Fare (information only): € 10.00 - Journey time: 45 to 60 minutes.<br /> <br /> <span style="color: #33cccc;"><strong><span style="color: #000000;">By taxi:</span> </strong></span>If you prefer to travel by taxi, Paris taxis will cost you roughly € 70 per journey.</li> </ul> </div> <h2> </h2> <h2>By train, from Paris' main SNCF stations</h2> <ul class="link-group"> <li><a href="http://www.sncf.com" target="_blank">SNCF</a></li> </ul> <div class="rich-text"> <p>Paris has several SNCF (railway) stations. Below are the routes which take you to the Institut Pasteur from the main stations. <br /> <br /> <strong>Montparnasse station</strong>: <br /> This is the closest station to the Institut Pasteur. You can either walk about 15 minutes or take the metro (line number 6 direction Charles de Gaulle - Etoile) to take you from Montparnasse-Bienvenue station to Pasteur station (one stop). <br /> <br /> <strong>Saint Lazare station</strong>: <br /> Take the metro (line number 12 direction Mairie d’Issy) from Saint-Lazare station to Pasteur station (about 20 minutes). <br /> <br /> <strong>Gare de Lyon station</strong>: <br /> Take the metro (line number 14 direction Bibliothèque François Mitterrand) to Bercy station. Change to line 6 direction Charles de Gaulle - Etoile and get off at Pasteur station. Journey time is roughly 35 minutes. <br /> <br /> <strong>Austerlitz station</strong>:<br /> Take the metro (line number 5 direction Place d’Italie) to the terminus at Place d’Italie. Change to line 6 direction Charles de Gaulle - Etoile and get off at Pasteur station. Journey time is roughly 30 minutes. <br /> <br /> <strong>Gare de l’Est station</strong>: <br /> Take the metro (line number 4) direction Porte d’Orléans to Raspail station. Then change to line 6 direction Charles de Gaulle - Etoile and get off at Pasteur station. Journey time is roughly 35 minutes. <br /> <br /> <strong>Gare du Nord station</strong>: <br /> Take the RER B direction Robinson or Saint-Rémy les Chevreuse to Denfert-Rochereau. Change and take the metro line 6 direction Charles de Gaulle – Etoile to Pasteur station. Journey time is roughly 35 minutes.</p> </div> <p> </p> <h2>Tourist information</h2> <div class="rich-text"> <p>Download the general information to organize your arrival in France and your stay in Paris (Institut Pasteur document). <br /> <br /> Visiting, cultural activities: <br /> <a href="http://en.parisinfo.com/" target="_blank">Paris Tourist Office Information</a> and <a href="http://www.paris.fr/portail/english/Portal.lut?page_id=8118" target="_blank">City hall of Paris</a> (Mairie de Paris) <br /> <br /> Paris, the good taste capital: <br /> Find a restaurant on <a href="http://en.parisinfo.com/paris_restaurants/" target="_blank">Paris Info</a> <br /> <br /> Weather: <br /> The <a href="http://weather.yahoo.com/forecast/FRXX0076.html" target="_blank">weather</a> in Paris today.</p> </div> <p> </p> </td> </tr> </tbody> </table></p> Persistance-webSoft - congreSoft© 38, rue Dunois - 75647 Paris Cedex 13 Téléphone : 09.50.07.41.63 Fax : 09.55.07.41.63 Email : contact@congresoft.fr Web : <a target=_blank href="http://www.persistance-websoft.com/">Persistance-webSoft</a> Une plateforme dédiée aux manifestations et évènements de toutes tailles <a target=_blank href="http://www.congresoft.fr/">congreSoft</a>